Discovery, Development, Target and off Target effects, Safety assessment, and Mode of Action studies
MicroMatrices unlocks the molecular and phenotypic information contained within tissue samples (fixed/frozen/fresh/organoid) by integrating molecular visualization/localization technologies with complementary ‘omics technologies.
With a highly skilled scientific core networked to facilities of excellence, MicroMatrices is scalable, efficient and flexible.
We offer our clients in the pharmaceutical and chemical industries innovative molecular phenotyping platforms for: Target & Off Target effects/Safety Asessment/Mode of Action Find Out More
SpheroMatrices – A spheroid tissue microarray (TMA) for 3D cell culture high-throughput histology
Visualizing xenobiotic/drug targets via IHC/ISH
In-situ hybridisation and immunostaining used in combination provide a powerful tool for mapping and visualizing drug and other xenobiotic targets.
Exploring MOA/Molecular mechanisms of toxicity
We integrate Transcriptomic & Proteomic profiling data from tissue (fresh/frozen/FFPE) to assess global expression and translation effects in response to drug/chemical exposure;
Supporting early discovery, development, and Product Life Cycle Maintenance
Assisting in the demonstration of non human relevance, and other compound registration issues.
Histology and Microphysiological systems (MPS)
In vitro 3D models are increasingly integral to drug discovery and drug development programs with many commercial safety…
Meet us in San Diego at SOT 2022
We look forward to re-connecting with clients/colleagues at the first on-site SOT in two years, held this year…
Transcriptomics with SpheroMatrices microTMA
The addition of a spatially defined overlay of transcriptomics to cytotoxicity/histological findings, or biomarker expression/localization image data, adds…
on an interactive, step by step basis. Collaborations can begin with pilot projects which can then be scaled up to larger research programs, according to your requirements.