Frontiers, Not Boundaries

Spatial transcriptomics with 3D models workshop

MicroMatrices are presenting at the “Novel Spatial, Molecular & Imaging Approaches to Analyse 3D Tissue Models” virtual workshop, organised by the Centre for 3D Models of Health and Disease, University College London, on 27 July 2021 14:00-18:00 BST. The aim of this workshop is to discuss new advances in endpoint analysis of 3D tissue models, including spatial…

Cross-Species Consortium for validating in vitro DILI models

MicroMatrices are providing histology services for an exciting new cross species consortium venture from InSphero.  SpheroMatrices microTMA technology is ideally suited for this purpose as it allows for side by side histological comparison of microtissues derived from different species on a single microscope slide. This important collaborative project aims to recapitulate DILI effects observed in…

See us at SOT 2021

 For reasons all too familiar to everyone,  SOT 2020 could not go ahead. The good news is SOT is back in 2021 and is an entirely virtual meeting between 12-27 March. We are presenting a poster entitled ” Species differences in phenobarbital-mediated UGT gene induction in rat and human liver 3D microtissues “; SOT 2021…

Newly publication: Toxicology Reports

“Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues” To test the utility of 3D liver microtissues for compound de-risking, we investigated the hypothesis that species differences in thyroxine metabolism by UGT could underlie differences in susceptibility to thyroid carcinogenesis in rats and humans. Using bioinformatic analysis of microarray and proteomics data derived from PB treated rat…

SpheroMatrices Technology Publication Tops 2019 list

Our publication featuring  the use of the SpheroMatrices® microTMA technology (patent pending)  was one of the top downloaded “Scientific Reports” cancer papers of 2019. With over 4000 downloads to date, our paper came 15th out of over 1000 cancer papers published during the year. Entitled “A Human iPSC-derived 3D platform using primary brain cancer cells…

Cross Species Risk Assessment in 3D Microtissues-SOT2020

We look forward to meeting clients and colleagues at the 59th annual meeting of the Society of Toxicology, held this year between 15-19 March in Anaheim, California. We will be presenting a poster entitled “Species differences in phenobarbital-mediated UGT gene induction in rat and human liver 3D microtissues”  (P340) in which we will describe how…

Multiplexed molecular phenotyping of tissues

Tissue samples are complex matrices of molecular information. While single endpoint investigations within samples support mechanistic understanding, multiplexed and integrated  investigations within the same tissue samples add valuable dimensionality to this understanding which better reflect complex biological responses to xenobiotics/stressors. MicroMatrices specialize in multiplexed interrogation of tissues. With our immunostaining capabilities, we can simultaneously visualise…

Presentation at “Epigenetics in Toxicology and Pathology”

MicroMatrices presented an oral presentation at a recent meeting entitled “Epigenetics in Toxicology and Pathology” held in Newcastle, UK, and hosted jointly by the British Society for  Toxicological Pathology (BSTP) and the British Toxicology Society (BTS). In a talk entitled “Cross species comparison of CAR mediated pro-carcinogenic key events in a 3D liver microtissue model”,…

New Toxicology Reports Publication

MicroMatrices are pleased to announce  a new publication entitled  “Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model”. Published  25 September 2019 in “Toxicology Reports”, the paper describes how our proprietary SpheroMatrices microTMA technology can be used in 3D rat and human liver microtissues to establish key events for CAR Mode of Action…

Detecting Key Tox Events using SpheroMatrices and 3D Liver Microtissues

Five key events* characterize constitutive androstane receptor (CAR) mediated liver carcinogenesis in rats, a process which is not human-relevant. Using SpheroMatrices technology, we have tested whether these events can be detected in 3D rat liver microtissues vs human liver microtissues. We treated rat and human liver microtissues with the prototypical CAR activator phenobarbital (PB)  over…

WE WORK WITH YOU…

on an interactive, step by step basis. Collaborations can begin with pilot projects which can then be scaled up to larger research programs, according to your requirements.