“Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues” To test the utility of 3D liver microtissues for compound de-risking, we investigated the hypothesis that species differences in thyroxine metabolism by UGT could underlie differences in susceptibility to thyroid carcinogenesis in rats and humans. Using bioinformatic analysis of microarray and proteomics data derived from PB treated rat…

Our publication featuring  the use of the SpheroMatrices® microTMA technology (patent pending)  was one of the top downloaded “Scientific Reports” cancer papers of 2019. With over 4000 downloads to date, our paper came 15th out of over 1000 cancer papers published during the year. Entitled “A Human iPSC-derived 3D platform using primary brain cancer cells…

We look forward to meeting clients and colleagues at the 59th annual meeting of the Society of Toxicology, held this year between 15-19 March in Anaheim, California. We will be presenting a poster entitled “Species differences in phenobarbital-mediated UGT gene induction in rat and human liver 3D microtissues”  (P340) in which we will describe how…

Tissue samples are complex matrices of molecular information. While single endpoint investigations within samples support mechanistic understanding, multiplexed and integrated  investigations within the same tissue samples add valuable dimensionality to this understanding which better reflect complex biological responses to xenobiotics/stressors. MicroMatrices specialize in multiplexed interrogation of tissues. With our immunostaining capabilities, we can simultaneously visualise…

MicroMatrices presented an oral presentation at a recent meeting entitled “Epigenetics in Toxicology and Pathology” held in Newcastle, UK, and hosted jointly by the British Society for  Toxicological Pathology (BSTP) and the British Toxicology Society (BTS). In a talk entitled “Cross species comparison of CAR mediated pro-carcinogenic key events in a 3D liver microtissue model”,…

MicroMatrices are pleased to announce  a new publication entitled  “Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model”. Published  25 September 2019 in “Toxicology Reports”, the paper describes how our proprietary SpheroMatrices microTMA technology can be used in 3D rat and human liver microtissues to establish key events for CAR Mode of Action…

Five key events* characterize constitutive androstane receptor (CAR) mediated liver carcinogenesis in rats, a process which is not human-relevant. Using SpheroMatrices technology, we have tested whether these events can be detected in 3D rat liver microtissues vs human liver microtissues. We treated rat and human liver microtissues with the prototypical CAR activator phenobarbital (PB)  over…

MicroMatrices are pleased to announce the publication 5 February 2019  of  a paper  entitled “A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine” in  Scientific Reports. This landmark paper describes the application of our proprietary SpheroMatrices microTMA technology in  a heterotypic human glioblastoma model containing normal neuronal cells…

SpheroMatrices is our proprietary technology for creating a tissue microarray from spheroid microtissues, capturing an entire 96 well experiment on a single microscope slide. The microtissues, aligned in two dimensions, can be serially sectioned for  immunostaining and image analysis. Please watch the SpheroMatrices video to learn more: This versatile technology can be applied for:  Model…

    We are pleased to announce the arrival of our new satellite website: www.spheromatrices.com showcasing our spheroid tissue microarray technology for multiplexed 3D cell culture analytics; don’t miss the video!