The addition of a spatially defined overlay of transcriptomics  to cytotoxicity/histological findings, or biomarker expression/localization image data, adds mechanistic underpinning to these findings. SpheroMatrices microTMA technology is a platform for analyzing both phenotype and transcriptomics in human-relevant  3D microtissue/MPS models. Following in life exposure to drugs/chemicals, microtissues are fixed and arrayed in a  single plane…

MicroMatrices are presenting at the “Novel Spatial, Molecular & Imaging Approaches to Analyse 3D Tissue Models” virtual workshop, organised by the Centre for 3D Models of Health and Disease, University College London, on 27 July 2021 14:00-18:00 BST. The aim of this workshop is to discuss new advances in endpoint analysis of 3D tissue models, including spatial…

MicroMatrices are providing histology services for an exciting new cross species consortium venture from InSphero.  SpheroMatrices microTMA technology is ideally suited for this purpose as it allows for side by side histological comparison of microtissues derived from different species on a single microscope slide. This important collaborative project aims to recapitulate DILI effects observed in…

 For reasons all too familiar to everyone,  SOT 2020 could not go ahead. The good news is SOT is back in 2021 and is an entirely virtual meeting between 12-27 March. We are presenting a poster entitled ” Species differences in phenobarbital-mediated UGT gene induction in rat and human liver 3D microtissues “; SOT 2021…

“Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues” To test the utility of 3D liver microtissues for compound de-risking, we investigated the hypothesis that species differences in thyroxine metabolism by UGT could underlie differences in susceptibility to thyroid carcinogenesis in rats and humans. Using bioinformatic analysis of microarray and proteomics data derived from PB treated rat…

Our publication featuring  the use of the SpheroMatrices® microTMA technology (patent pending)  was one of the top downloaded “Scientific Reports” cancer papers of 2019. With over 4000 downloads to date, our paper came 15th out of over 1000 cancer papers published during the year. Entitled “A Human iPSC-derived 3D platform using primary brain cancer cells…

We look forward to meeting clients and colleagues at the 59th annual meeting of the Society of Toxicology, held this year between 15-19 March in Anaheim, California. We will be presenting a poster entitled “Species differences in phenobarbital-mediated UGT gene induction in rat and human liver 3D microtissues”  (P340) in which we will describe how…

Tissue samples are complex matrices of molecular information. While single endpoint investigations within samples support mechanistic understanding, multiplexed and integrated  investigations within the same tissue samples add valuable dimensionality to this understanding which better reflect complex biological responses to xenobiotics/stressors. MicroMatrices specialize in multiplexed interrogation of tissues. With our immunostaining capabilities, we can simultaneously visualise…

MicroMatrices presented an oral presentation at a recent meeting entitled “Epigenetics in Toxicology and Pathology” held in Newcastle, UK, and hosted jointly by the British Society for  Toxicological Pathology (BSTP) and the British Toxicology Society (BTS). In a talk entitled “Cross species comparison of CAR mediated pro-carcinogenic key events in a 3D liver microtissue model”,…

MicroMatrices are pleased to announce  a new publication entitled  “Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model”. Published  25 September 2019 in “Toxicology Reports”, the paper describes how our proprietary SpheroMatrices microTMA technology can be used in 3D rat and human liver microtissues to establish key events for CAR Mode of Action…