MicroMatrices are providing histology services for an exciting new cross species consortium venture from InSphero. SpheroMatrices microTMA technology is ideally suited for this purpose as it allows for side by side histological comparison of microtissues derived from different species on a single microscope slide.
This important collaborative project aims to recapitulate DILI effects observed in vivo with a wide range of compounds in microtissues of the same species. Results showing biochemical, histological and mechanistic correlation between in vivo and in vitro animal models for a wide range of DILI-inducing compounds will provide strong evidence for an analogous correlation between human liver microtissues and man, strengthening the case for routine inclusion of these models in pre-clinical assessments of new therapeutics for DILI toxicity.
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Histology and Microphysiological systems (MPS)
In vitro 3D models are increasingly integral to drug discovery and drug development programs with many commercial safety…
Meet us in San Diego at SOT 2022
We look forward to re-connecting with clients/colleagues at the first on-site SOT in two years, held this year…
Transcriptomics with SpheroMatrices microTMA
The addition of a spatially defined overlay of transcriptomics to cytotoxicity/histological findings, or biomarker expression/localization image data, adds…
on an interactive, step by step basis. Collaborations can begin with pilot projects which can then be scaled up to larger research programs, according to your requirements.