MicroMatrices specializes in pathology-guided high resolution tissue analyses which can localize/visualize biomarkers, using immunohistochemistry/in situ hybridisation, within specific cell types.
We can apply the same approach in parallel tissue sections to select specific regions for transcriptomic and/or proteomic, and downstream bioinformatic analyses.
These approaches can generate mechanistic hypotheses that facilitate the design of prospective in vitro studies to better assess the human relevance of adverse effects identified in vivo .
Services can be provided for fixed/frozen/fresh/organoid tissue samples
Retrospective StudiesMicroMatrices can extract RNA and protein from FFPE tissue for miRNA, mRNA and proteomic profiling ; in addition, we can analyze parallel sections of these same tissue samples to localize biomarkers to specific cell types within the tissue.
When applied to archival bioassay study samples, this approach unlocks the data within historic samples and can identify potential biomarkers for prospective studies, minimizing the need for new animal experiments.
Please contact us to discuss your project.
Newly publication: Toxicology Reports
“Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues” To test the utility of…
SpheroMatrices Technology Publication Tops 2019 list
Our publication featuring the use of the SpheroMatrices® microTMA technology (patent pending) was one of the top downloaded…
on an interactive, step by step basis. Collaborations can begin with pilot projects which can then be scaled up to larger research programs, according to your requirements.