MicroMatrices specializes in pathology-guided high resolution tissue analyses which can localize/visualize biomarkers, using immunohistochemistry/in situ hybridisation, within specific cell types.
We can apply the same approach in parallel tissue sections to select specific regions for transcriptomic and/or proteomic, and downstream bioinformatic analyses.
These approaches can generate mechanistic hypotheses that facilitate the design of prospective in vitro studies to better assess the human relevance of adverse effects identified in vivo .
Services can be provided for fixed/frozen/fresh/organoid tissue samples
Retrospective StudiesMicroMatrices can extract RNA and protein from FFPE tissue for miRNA, mRNA and proteomic profiling ; in addition, we can analyze parallel sections of these same tissue samples to localize biomarkers to specific cell types within the tissue.
When applied to archival bioassay study samples, this approach unlocks the data within historic samples and can identify potential biomarkers for prospective studies, minimizing the need for new animal experiments.
Please contact us to discuss your project.
Histology and Microphysiological systems (MPS)
In vitro 3D models are increasingly integral to drug discovery and drug development programs with many commercial safety…
Meet us in San Diego at SOT 2022
We look forward to re-connecting with clients/colleagues at the first on-site SOT in two years, held this year…
Transcriptomics with SpheroMatrices microTMA
The addition of a spatially defined overlay of transcriptomics to cytotoxicity/histological findings, or biomarker expression/localization image data, adds…
on an interactive, step by step basis. Collaborations can begin with pilot projects which can then be scaled up to larger research programs, according to your requirements.